Synthesis, characterization, antimicrobial screening and cytotoxic properties of Cu(II) and Zn(II) complexes with bidentate hydroxylated 1,3-diaryl-2-propene-1-ones ligand

A series of binary metal complexes (halo, hydroxyl and methoxy substituted bis(2-(E)acryloyl)naphthalen-1-yl)oxy)Cu(II) Zn(II) (C1? ?C10)) Cu2+ Zn2+ ions derived from bi-coordinated hydroxylated 1,3- -diaryl-2-propene-1-ones were synthesized. The newly synthesized structurally determined by FT-IR, 1H-NMR, 13C-NMR, ESR spectral, XRD TGA analyses. FT-IR studies demonstrated that interactions between with ligands occur through carbonyl oxygen deprotonated correspond to square-planar geometry for all complexes. screened in-vitro evaluated their antimicrobial cytotoxic activities. C1 C4 showed significant activity while the remaining moderate against tested pathogens. organism Artemia salina. Complexes C2?C5 exhibited LC50 values 630.45, 969.99, 921.94 918.41 ?M mL-1, respectively. Furthermore, anticancer liver cancer cell line Hep G2 in comparison 5-fluorouracil standard. Complex C5 a IC50 value 58.94 ?g mL-1. Therefore, present study is useful development new class agents.